Biochemical Mechanism of Acetaminophen (APAP) Induced Toxicity in Melanoma Cell Lines
نویسندگان
چکیده
منابع مشابه
The protection of glycyrrhetinic acid (GA) towards acetaminophen (APAP)-induced toxicity partially through fatty acids metabolic pathway.
BACKGROUND Acetaminophen (APAP)-induced liver toxicity remains the key factor limiting the clinical application of APAP, and herbs are the important sources for isolation of compounds preventing APAP-induced toxicity. AIMS To investigate the protection mechanism of glycyrrhetinic acid towards APAP-induced liver damage using metabolomics method. METHODS APAP-induced liver toxicity model was ...
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Previously, we reported that acetaminophen (APAP) showed selective toxicity towards melanoma cell lines. In the current study, we investigated further the role of tyrosinase in APAP toxicity in SK-MEL-28 melanoma cells in the presence of a short hairpin RNA (shRNA) plasmid, silencing tyrosinase gene. Results from tyrosinase shRNA experiments showed that APAP led to negligible toxicity in shRNA ...
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Acetaminophen (APAP) toxicity threatens human health due to increased mortality associated with its overdose. Doxycycline (DC) because of its properties such as antioxidant and anti-inflammatory can be a good therapeutic strategy to treat the acute toxicity induced by APAP. Male mice were divided to six groups in two periods of 3 and 24-h as normal saline, APAP 400 mg/kg, DC 100 mg/kg and group...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2009
ISSN: 0022-3549
DOI: 10.1002/jps.21505